Abstract A search for the doubly charmed baryon Ω cc + with the decay mode Ω cc + → Ξ c + K − π + is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb −1 . No significant signal is observed within the invariant mass range of 3.6 to 4.0GeV/ c 2 . Upper limits are set on the ratio R of the production cross-section times the total branching fraction of the Ω cc + → Ξ c + K − π + decay with respect to the $$\Xi _{cc}^{ + + } \to \Lambda _c^ + {K^ - }{\pi ^ + }{\pi ^ + }$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msubsup> <mml:mi>Ξ</mml:mi> <mml:mrow> <mml:mi>c</mml:mi> <mml:mi>c</mml:mi> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mo>+</mml:mo> </mml:mrow> </mml:msubsup> <mml:mo>→</mml:mo> <mml:msubsup> <mml:mi>Λ</mml:mi> <mml:mi>c</mml:mi> <mml:mo>+</mml:mo> </mml:msubsup> <mml:msup> <mml:mi>K</mml:mi> <mml:mo>−</mml:mo> </mml:msup> <mml:msup> <mml:mi>π</mml:mi> <mml:mo>+</mml:mo> </mml:msup> <mml:msup> <mml:mi>π</mml:mi> <mml:mo>+</mml:mo> </mml:msup> </mml:mrow> </mml:math> decay. Upper limits at 95% credibility level for R in the range 0.005 to 0.11 are obtained for different hypotheses on the Ω cc + mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/ c .