Entamoeba histolytica infection is common in developing countries such as Colombia. Its clinical presentation is variable and not very specific. Within this variety, ameboma is arare manifestation characterized by tumor growth secondary to the formation of granulation tissue in the colonic walls. This growth can be indistinguishable from a neoplasm, so a high index of clinical and endoscopic suspicion must be present to make an adequate diagnostic and therapeutic approach. We present the case of a patient with amebiasis, whose symptoms and imaging presentation were mistaken for colon carcinoma with liver metastases.