Banana passion fruit production in Colombia contributes to the development of the country’s economy as it generates income and provides raw material for the agro-based industries. Profitability is a key aspect of economic efficiency and plays an important role in farmer´s decision-making therefore; the purpose of the study was to determine the different factors affecting the economic profitability of banana passion fruit production. A descriptive, quantitative, correlational and non-experimental design was selected and a regression analysis was performed. Results showed that the stationarity, normality, homoscedasticity and non-autocorrelation assumptions were not violated; all estimated coefficients were statistically significant and consistent with hypothesized sign. As such, the independent variables contributed to explain individually banana passion fruit economic profitability.