Waldenstrom's macroglobulinemia (WM) or Waldenstrom's disease is a neoplasm that represents between 1 and 2% of non-Hodgkin's lymphomas.It is defined as a lymphoplasmacytic lymphoma associated with the presence of a monoclonal immunoglobulin of the IgM subtype that most frequently affects individuals between 63 and 75 years of age (1).It manifests itself through the signs and symptoms caused both by the presence of the monoclonal protein and by the infiltration produced by the tumor.Anemia and fatigue are the most frequent findings at the time of diagnosis. However, most patients remain asymptomatic for long periods, accounting for the chronic and indolent nature of this condition. The objective of this work is to carry out a bibliographic review in order to evaluate which are the treatment strategies and to try to determine the schemes that achieve the best results. In turn, a retrospective observational analysis is carried out on a group of patients with a diagnosis of WM who have undergone treatment, in order to compare the results obtained with the available bibliography.