Nowadays is quite common to have seismic data in the depth domain, generally from prestack depth migration (PSDM, isotropic or anisotropic) workflows. In several cases, PSDM images are obtained to resolve structural problems of the subsurface, however, in the recent years, several authors have demonstrated that we can use seismic images in the depth domain for seismic reservoir characterization, getting the advantages of working directly in this domain instead of converting seismic data from Depth to Time to Depth, which is the workflow that many geoscientists do right now. We developed a workflow integrating well log data, analysis between elastic parameters and rock types and PSDM seismic data in order to perform a simultaneous seismic inversion, getting the spatial distribution of the impedances related to sand lithology in Palagua field, Colombia. The volumes of elastic parameters indicates areas with low Vp/Vs ratio and low P impedances that are correlated with sand bodies in the field, with the advantage of working directly in the depth domain.