BACKGROUND AND AIM: At present, the human being has sought different alternatives to improve their health, taking into account more naturalistic approaches to the treatment of problems related to the cardiac, digestive and nervous system. The latter can be related to parasites, which cause substantial deaths and morbidity in humans and diseases in livestock and domestic animals. Traditional medicine has been used to combat parasitic diseases, using tea from seeds of several fruits. METHODS: In this opportunity, the effectiveness in the antiparasitic activity of the aqueous extract of avocado and papaya seeds was evaluated using the soil nematode Caenorhabditis elegans as a model, through mortality as an endpoint of acute toxicity. Three solutions of each extract in distilled water (50, 75, 100%) were used to exposure L4-stage larvae of C. elegans wild type Bristol N2 for 24 h. RESULTS:Results indicate a high anthelmintic activity of the two seed extracts, with 86, 91, 94% of mortality with the respective concentration of the avocado seed extract and 63, 76, 90% with the extract of papaya seeds; showing a dose-dependent mortality curve. CONCLUSIONS:The above demonstrates the anthelmintic power of the avocado and papaya seeds and the ability of C. elegans to be used as a model to study anthelmintic activity due to the similarity of the physiological characteristics that shares with the parasitic nematodes that affect health of human beings. KEYWORDS: Toxicology, Food/nutrition, Health co-benefits