Introduction: Hidradenitis suppurativa (HS) is an underdiagnosed and undertreated skin affection. Previous studies suggest that psychiatric conditions are more frequent in patients with HS than in other dermotologic diseases. In Colombia, we found no descriptive studies of its comorbidities. We described the HRQoL in patients with HS and its relationship with some comorbidities. Materials and Methods: We performed a descriptive and retrospective study in patients with HS in a dermotologic center in Bogotá, DC. We analyzed 24 patients attended from January 2017 to August 2020, assessing variables as age, sex, body mass index (BMI), and comorbidities. The dermatology life quality index (DLQI) and Hospital Anxiety and Depression scale (HAD) were applied in 19 patients. Univariate analysis and nonparametric statistics were performed. Data was collected and analyzed in Microsoft Excel 365 and SPSS26. Results: Of 24 patients, 18 were women (75%). The median age was 30 years old (IQR 21). The most frequently found comorbidities were acne and cardiovascular disease, 35.5% and 20.8%, respectively. DLQI’s most frequent result was a very large effect in 26.3% (n = 5). HADS-A showed anxiety in 6 cases (31.6%). HAD-D showed depression in 2 patients (10.5%). Conclusion: We found a greater association with acne and cardiovascular disease, which suggests a systemic and inflammatory involvement of the disease. Our findings related to HADS-A and DLQI reveal a great impact on the HRQoL and existence of anxiety symptoms, reinforcing the importance of multidisciplinary management. Further, larger studies are needed to validate these findings.