Background: Myofibroblastic inflammatory tumors are a group of mesenquimatous tumors that have predilection for children and young adults. It´s diagnose represents a challenge due to the unspecific symptoms and image studies findings. The definitive diagnose is given by characteristic histopathological findings. The complete tumor resection is the accepted treatment. Case Presentation: A 21 year old woman with previous history of one year of abdominal pain, localized on the epigastrium, accompanied with fever, asthenia, adynamia and weight loss. Laboratory exams showed microcytic anemia and thrombocytosis. The computerized tomography showed a cystic heterogeneous tumor on the left hepatic lobe. Patient underwent a laparotomy finding a cystic tumor on hepatic segments II and III, surgical resection was made with any complications. The histopathological study reported a myofibroblastic inflammatory tumor. Conclusiones: Myofibroblastic inflammatory tumors are entities difficult to diagnose. A radical resection should be considered for its treatment with patient follow up due to its potential recurrence.