We present new $ν_μ\rightarrowν_e$, $ν_μ\rightarrowν_μ$, $\overlineν_μ\rightarrow\overlineν_e$, and $\overlineν_μ\rightarrow\overlineν_μ$ oscillation measurements by the NOvA experiment, with a 50% increase in neutrino-mode beam exposure over the previously reported results. The additional data, combined with previously published neutrino and antineutrino data, are all analyzed using improved techniques and simulations. A joint fit to the $ν_e$, $ν_μ$, $\overlineν_e$, and $\overlineν_μ$ candidate samples within the 3-flavor neutrino oscillation framework continues to yield a best-fit point in the normal mass ordering and the upper octant of the $θ_{23}$ mixing angle, with $Δm^{2}_{32} = (2.41\pm0.07)\times 10^{-3}$ eV$^2$ and $\sin^2θ_{23} = 0.57^{+0.03}_{-0.04}$. The data disfavor combinations of oscillation parameters that give rise to a large asymmetry in the rates of $ν_e$ and $\overlineν_e$ appearance. This includes values of the CP-violating phase in the vicinity of $δ_\text{CP} = π/2$ which are excluded by $>3σ$ for the inverted mass ordering, and values around $δ_\text{CP} = 3π/2$ in the normal ordering which are disfavored at 2$σ$ confidence.