In the discussion about the role of the State in the economy, one of the main responsibilities of the regions is to create and strengthen conditions of competitiveness, growth and innovation of the territorial productive systems. One of the ways to produce these impulses is public investments in innovation. In Colombia, the General System of Royalties is the instrument through which state resources are dedicated for investment in Science, Technology and Innovation or CTeI. Through the fund for the CTeI of the system. This research studies the way in which the regions in Colombia have been using the resources of royalties to promote processes of technological and productive innovation so that the regional economic sectors compete in the national markets, in conjunction with the actors and organizations that are part of their productive and institutional environment.