This chapter establishes a tripartite relationship of high impact and validity in the business world. The three concepts that are intertwined are the management of human talent, the concept of disruption, and business strategy as drivers in organizations that seek to fulfill the visionary unit that has been proposed in the existing conditions of a particular environment that presents new movements, questions, and events derived from factors such as public health, the fourth industrial revolution, caring for the environment, generational social interaction. Once the concepts described above have been understood, the authors proceed to establish the relationship that allows them to intertwine and find the points of convergence so that they can have the proposal to manage human talent in times of disruption as a business sustainability strategy.