Transient global amnesia (TGA) is an unusual neurological syndrome of unknown etiology that affects individuals between 50 and 75 years old. We describe the case of a 61-year-old woman, who experienced an episode of two hours of anterograde amnesia. The event had an acute onset and was observed by a reliable witness. It lacked motor or sensory symptoms, compromised consciousness, or personal identity. A brain magnetic resonance was performed 22 hours after the onset of symptoms depicting foci of restricted diffusion in both hippocampi. Taking into account clinical and imaging findings, the diagnosis of transient global amnesia was made.