This article briefly reviews the pandemics suffered by humankind throughout its history. Additionally, it analyzes the current pandemic caused by a "strange" virus that has generated a new and complex disease. A description of its "new" vascular wall-centered physiopathology (and more specifically from the endothelium) is given. Moreover, the possibility to detect a subclinical endothelial dysfunction in young patients who have shown different susceptibility and lethality indices is considered. Finally, the question "will this pandemic change us or will it help us change?" is attempted to be answered.