A greater negative impact of exposure to air pollution on the health of people with greater susceptibility as those with comorbidities is recognized. The aim of this study was to establish the risk of dying at all times of people diagnosed with Chronic Lower Respiratory Tract Disease (CLRTD) (ICD10: J40-J47) and malignant tumors of the respiratory organs (MTRO) (ICD10: C30-C34) associated to PM10, PM2.5 and ozone exposures in each of the 10 municipalities of the Aburrá Valley region. A descriptive study with ecological exposure was developed from the individual service provision records and death records of each of the municipalities. An analysis that prioritized the construction of explanatory models of Cox proportional hazards was carried out. The outcome of interest was the time in years elapsed from the moment the patient was attended in the health system for first time by the chronic event until the time of death for the event or until the follow-up period ended (2008-2017). During the 10 years of the study, 330,171 cases of CLRTD and 9,990 of MTRO were reported, among which there were 13,824 and 8,585 deaths from these causes respectively. Exposure to PM10 was associated with increases in the risk of dying from CLRTD (14% to 21% for over 65 years old and between 15% and 25% over than 30 years old) and MTRO (between 2% and 8% older than 65 years and between 8% and 26% for people over 30) also, exposure to ozone was associated with the increased risk of dying from COPD (between 20% and 47% for people over 65 and between 16% and 36% for people over 30).