Air pollution is one of the most significant environmental problems of public health in Colombia. The study aimed to carry out an analysis of the relationship between air quality and the incidence of respiratory diseases in communes 4, 6, 7 & 8 of the municipality of Cúcuta. Thanks to the application of a quantitative and descriptive methodology with a correlational approach, a Citizen Perception Survey was designed. Also, concentrations of the particulate material (PM10) of El Salado and Atalaya areas were analyzed together with analysis of the burden of disease according to the records provided by (IMSALUD) & (IDS). The results show a dependent association between the study variables. Additionally, it shows a significant trend for acute Rhinopharyngitis in vulnerable patients (children and older adults) and a favorable air quality status for the months evaluated (May – July / 2018).