This paper investigates the findings regarding the fecal food contamination indicator and disease prevention, with the purpose of giving importance to the causes that are in recurrence in the health, sanitary and biological area. With the demonstration of the studies on microorganism and ascertaining their respective modes of contracting them, the differentiated forms of treatment and the diagnosis, the underlying consequence and the aggravations resulting from ineffective treatments. The presentations of fecal contamination feed the prevention measures related to E. coli. When the diagnosis of E.coli is done, it is understood that E.coli affect organs and / or systems after they leave the intestine, but their sides have convergence since E. coli also contributes to digestive functioning in the sense of absorption of nutrients and are mostly harmless