ABS TRACT Objective: Due to the coronavirus disease-2019 (COVID-19) pandemic, there have been major changes in the way almost every business works.This study examines the relationship between the changing working conditions [working from home (WFH)] related to COVID-19 on low back pain (LBP) and the associated kinesiophobia, disability, physical activity, and job satisfaction.Material and Methods: One-hundred-one white-collar workers who were WFH were included in the study, and demographic characteristics, presence of LBP, and other musculoskeletal disorders were questioned.Numerical Rating Scale for low-back pain and other musculoskeletal pain, Oswestry Disability Index (ODI) for determination of disability level, Tampa Scale of Kinesiophobia (TSK) for the presence of kinesiophobia, International Physical Activity Questionnaire (IPAQ)for physical activity level, and Utrecht Work Engagement Scale-6 (UWES-6) questionnaire for job satisfaction were applied via an online survey.Results: Of the participants 56.4% had LBP.The most common musculoskeletal disease following LBP was neck pain and/or dorsalgia (39.6%).The ODI (p<0.001),TSK (p <0.001) and the presence of kinesiophobia (p=0.016) were higher in participants with LBP.LBP was positively correlated with the ODI and TSK (r=0.489;p=<0.001,r=0.409; p=<0.001), and the other musculoskeletal pain has a positive correlation with the ODI (r=0.228;p=0.023).No relationship was found between UWES-6 and IPAQ with LBP.Conclusion: During the COVID-19 pandemic, white-collar workers WFH with LBP experience higher kinesiophobia and disability.Disability is increasing with LBP level and other musculoskeletal disease pain level.There was no relationship between the presence of LBP with job satisfaction and physical activity level.