Microbes microorganisms grow in two states, biofilm and planktonic cell, in the case of biofilms.When planktonic cells adhere to a surface, they exhibit behaviors described as "reversible" and "irreversible" patterns, being the cell adhesion a key point for the formation of biofilms.It estimates that 80 % of human infections are caused by biofilms and 65 % of nosocomial infections are generated by the growth of these micro-colonies in biomedical devices and human tissues.Polymicrobial biofilms are responsible of pathologies in higher living organisms, plants, animals and humans.Polymicrobial biofilms are understood to be those microbial communities that have high resistance and tolerance to antibiotics, formed by microbial groups made up of more than one type of microorganisms, which, among them, develop different symbiotic mechanisms to coexist in a common space.This area is still with high potential for microbiological research due to there are mechanisms of their growth and interaction that are not yet understood.This review aims to contribute with concepts and studies that promote these investigations, with the aim of being closer to an effective treatment that allows reducing the impact generated by polymicrobial biofilms on human health, food and biotechnology industries, among others.