Nowadays, in the medicine, the design and obtaining of biocompatible and biodegradable materials, with specific functional and structural properties, are highly required.In this way, hydrogels have been suggested as potential materials meeting these requirements, therefore, new alternative of hydrogels with adaptable properties are desired for many technological applications.But also, polyureas based on isocyanates and amines have emerged as a simple and quick alternative to obtain functional hydrogels to be used in biomedical and pharmacological applications.Thus, the objective of this research was to obtain biocompatible and biodegradable polyurea-base functional materials.For that, a multicomponent reaction between 1,6-hexamethylene diisocyanate, sorbitol and L-cysteine under moderate conditions and in presence of water was developed.For this, the hydrogels were synthesized through multicomponent reactions at 60 °C for 24 h varying the amounts of cysteine and sorbitol.The polyurea-base hydrogels obtained were structurally characterized by Fourier-transform infrared spectroscopy (FTIR-ATR) in conjunction with functionally-enhanced derivative spectroscopy (FEDS) and solid-state carbon-13 nuclear magnetic resonance ( 13 C-NMR).Finally, the thermal stability of the materials was determined by thermogravimetric analysis and its water absorption capacity at different pH values (1.0, 7.0 and 12.0) was determined by gravimetric method.It was concluded that the multi-component reaction methodology allowed to obtain polyurea-base hydrogels with high water retention.