To perform a descriptive analysis of the diagnosis of ductus venosus agenesis (DVA) evidenced during 1st trimester screening in a referral centre in Colombia. Descriptive study based on 4608 patients referred for 1st trimester prenatal screening (2015 – 2019). All US where performed by OB FMF certified. All cases had a complete assessment of US markers for aneuploidies. All cases were revaluated by two other observers. Cases were followed up and neonatal outcome was obtained. 8 fetuses were diagnosed with DVA. The mean GA at diagnosis was 12.6 weeks (SD 0.33). In 6 fetuses the ultrasound findings corresponded to intrahepatic DVA and 2 to an extrahepatic drainage type. Of the 6 cases of intrahepatic DVA, 2 (33%) had a poor outcome. 1 was a DC twin with an associated SUA who presented a spontaneous loss. Of the 2 cases with extrahepatic DVA, 1 corresponded to a fetus with T21 with a cardiopathy that elected a TOP. The 2nd case corresponded to a DC twins in which both fetuses had an augmented NT. 1 of the fetuses had an extrahepatic DVA with a right auricle drainage and IUGR with cardiopathy. The fetus had an spontaneous loss. Of the total number of cases, 62.5% had a normal perinatal outcome. 25% had an associated cardiopathy and/or IUGR. And 12.5% had a spontaneous fetal loss. Of the extrahepatic type cases, 1 had right atrium drainage, while the other drained into the IVC. Only 1 fetus had an aneuplody (T21), which corresponded to an extrahepatic type case. Complete US evaluation for 1st trimester markers of aneuplodies confers the opportunity for early diagnosis of DVA. 1st trimester diagnosis allows evaluation for drainage type, associated anomalies, and determination of prognosis. Isolated DVA, and more often the intrahepatic type may be compatible with normal fetal development. 1st trimester diagnosis of DVA is feasible as part of a routine protocol of complete ultrasound marker screening in the scenario of a referral centre.