The history of liver is full of anecdotes that go back to the origins of humanity. The ancients considered it to be the main organ of the body, where the soul and human emotions lived, and for this reason it has also been the place where temperaments are housed, including the biliary one. Some also linked the liver to pleasure: the words hepatic and hedonistic are believed to share the same root. In the period of Elizabeth I, Queen of England, the monarch was the “Liver of the Nation”.