This book is the product of an institutional research project that seeks to carry out a theoretical and empirical contribution on culture and organizational change, variables important in organizational dynamics. This work addresses the perspective of organizational culture considering various topics that allow understanding their relations with other variables and in turn identifying how the organizational change is a construct that has an important impact on the organization. Therefore, the acceptance or rejection of changes in organizations will depend somehow on the organizational culture that is reflected in the organization. Finally, the connection between the variables under study is presented as a case study.