Trigeminal ganglion (TG) is the main sensory ganglion of the orofacial regions associated with neuropathic pain.TG comprises pseudo-unipolar neurons with different morphologies and two types of glial cells, including Schwann cells and satellite glial cells (SGC).We designed this study to examine the effects of tooth extraction (as a cause of neuropathic pain) on the morphological and population change in SGC and neurons of the TG in aged and young adult animals.The results of our current study revealed that tooth extraction is not associated with quantitative changes in the number of SGC and leads to morphological changes in heterogeneous SGC of the ipsilateral side.The hypertrophic SGC was the most striking microscopic feature of the study.Additionally, quantitative changes in the pattern distribution and morphometry of neurons and the dynamic nature of the TG after tooth extraction particularly in aging was the other finding of our study.