Introduction: Esthesioneuroblastoma (olfactory neuroblastoma) is a malignant neoplasm, possibly originating from the basal neural cells of the olfactory mucosa that compromises the superior portion of the nasal cavity. Even rare among sinonasal malignancies accounting for approximately 3% of all nasal cavity tumors, has a slight male and probably no ethnicity or age predominance. A combination of surgical resection, radiotherapy, and chemotherapy is used for its treatment. With modern endoscopic-endonasal techniques, a minimally invasive safe single-stand gross total resection can be achieved. We present an operative video describing a pure endoscopic endonasal transcribiform approach for the resection of an esthesioneuroblastoma Kadish C.