Nowadays the search for new sustainable processes has been a central theme in the context of developing new materials.In that respect, the same perspective has been used by researches looking for obtaining new biomaterials.Hydroxypolyurethanes (PHU's) obtained using a methodology that uses the green route of CO2 fixation methodology can be an interesting way to deal with the challenge of producing sustainable polymeric materials.In this regard, the Group of Chemistry of Hybrid and Inorganic Materials (GQMatHI) has carried out research about the development of hydroxyurethanes derived from PDMS (hereafter named PDMSUr) with a special focus on the development of biomaterials.The aim of this work was to develop methodologies for obtaining PDMSUr hybrids with calcium phosphate, aiming at its potential use in bone reconstruction and repair and fixation/adhesion agent of implants applied in dentistry and or orthopedics.For that, a PDMSUr formulation was developed and three methodologies for obtaining composite were tested: Physical Mixing Method (MMF), Reactive Synthesis Method (MSR), Alternating Soaking Method (MIA).Among them, the MSR was not interesting because the final material had a low content of calcium phosphate and the polymeric matrix lost its ability to cure.The characterization results indicate that the Composites were obtained successfully by MMF (Comp MMF) and MIA (Comp MIA).The first method is suitable for situations in which the PDMSUr matrix is not yet cured (reticulated).On the other hand, the MIA is for already reticulated PDMSUr.Unlike the traditional MIA reported in the literature, the present study reports the first non-aqueous MIA protocol.This particularity gives an advantage of being able to mineralize calcium phosphates in hydrophobic matrices, a condition that the original method of MIA does not contemplate.The main calcium phosphate phase formed using MIA protocol was anhydrous dicalcium phosphate (DCPA), which is an interesting phase for bone regeneration applications, therefore the Comp MIA has the potential to be used in studies with this purpose.The PDMSUr and Comp MIA membranes showed antimicrobial activity for all tested microorganisms.In addition, the PDMSUr membrane in the preliminary cytotoxicity assay proved to be cytocompatible.Therefore, the materials developed in the present study are to go to the next testing phase to become a hybrid biocompatible material for orthopedics and orthodontics.