The use of ultrasound in regional anesthesia plays an important role in determining the variable anatomical structures and their localization. In these days, developments in ultrasonography devices and probes, hardware, and software technologies such as real-time needle tip tracking are increasing rapidly. Artificial intelligence-powered ultrasonography is one of them. In this case report, we aimed to present three cases where regional block was applied using artificial intelligence-powered (Nerveblox) ultrasound. Infraclavicular nerve block to two of our patients and pectoral nerve block to the third one were applied successfully once at a time. None of the patients developed vascular puncture or local anesthetic toxicity. The use of artificial intelligence support in peripheral nerve blocks may reduce the number of attempts and duration of interventions.