Pemphigus Foliaceus is a frequent autoimmune dermatopathy, which can develop either spontaneous, secondary to the use of drugs, or correlated to neoplasms. The different presentations of the Pemphigus complex are accompanied with the existence of antibodies attacking desmosomal proteins that join together the keratinocytes. Lesions may be localized or generalized, and are usually found in the face, nasal planum, auricular area, abdominal region, and in some cases, in paw pads. The diagnosis is based on clinical history, clinical signs, and cytology and histopathology results. The management of Pemphigus Foliaceus is based on administration of immunosuppressive agents. The case report. Canine Pinscher breed, female, castrated, 11 years old, 2 kg weight, coexisting with 2 adult dogs without clinical signs. There are no injuries in the people at home, and their reason for consultation was hair loss, intense scratching and grains. Trichogram, skin scrapings, cytology and histopathology of pustules were used as diagnostic plan. The results of the latest tests had acantholytic cells in common, for which Pemphigus Foliaceus was diagnosed and therapy with oral prednisolone and chlorhexidine shampoo baths were established. Conclusion. The importance of doing first intension testing as trichogram, scraping, and cytology is once again demonstrated, as well as the importance of the use of a histopathological study to obtain an accurate diagnosis and to establish an adequate therapy.