Periodontitis is a disease that generates inflammation of the periodontal junction complex and is one of the main causes of oral morbidity in the world.The aim of this study was to analyze the relationship between periodontitis and antibiotic therapy in the last decades.Data collection was carried out using the Scopus database, and "antibiotic" and "periodontitis" were the terms used in the search during a time span of 1948-2020.VOSviewer 1.6.13 was used for data analysis and visualization.A total of 688 documents related to periodontal disease and antibiotic therapy were indexed in Scopus between 1953 and May 25, 2020.Studies related to this topic have been on the rise since the 1970s, and the main areas were (i) Medicine, (Ii) Dentistry, and (Iii) Immunology and Microbiology, where the studies were focused on infection, disease, microbiology, and treatment.Most used antibiotics for periodontal disease were metronidazole and amoxicillin, but Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia/nigrescens exhibited resistance to these antibiotics probably due to their natural tolerance or excessive use.The countries that published the most studies on antimicrobial resistance in periodontics and had the strongest collaboration network were the United States, Germany, the United Kingdom, and Switzerland.