The interest of the construction industry in alkali-activated materials has increased to the extent that these materials are recognized as alternatives to ordinary Portland cement-based materials in the quest for sustainable construction. This article presents the design and construction of a prototype of an eco-friendly house built from concrete blocks produced using alkali activation technology or geopolymerization. The prototype meets the requirements of the current Colombian Regulations for Earthquake Resistant Buildings (NSR-10) and includes standards related to the performance of the materials, design, and construction method for earthquake-resistant confined masonry of one- or two-story buildings. The alkali-activated blocks were obtained from different precursors (aluminosilicates), including a natural volcanic pozzolan, ground granulated blast furnace slag, fly ash, construction and demolition waste (concrete, ceramic, brick, and mortar), and red clay brick waste. The physical-mechanical characterization of the alkali-activated blocks allowed their classification according to the structural specifications of the Colombian Technical Standard NTC 4026 (equivalent to ASTM C90). The global warming potential (GWP) or “carbon footprint” attributed to the raw materials of alkali-activated blocks was lower (25.4–54.7%) than that of the reference blocks (ordinary Portland cement concrete blocks). These results demonstrate the potential of alkali-activated materials for application in the construction of eco-friendly houses.