Aims & Objectives: To systematically summarize all pediatric cases in the literature with acute liver failure and severe dengue infection, compare their findings, including our own case. Methods: We searched in EMBASE, LILACS, PUBMED and EBSCO using: liver failure and dengue, limited to less than 18 years old, up to December 2017. Reports were included if they were in English or Spanish, and reported a least a case of liver failure secondary to dengue fever. We also included our case. We describe country, year, age, dengue severity, lab results, mortality, and length of hospital stay. Results: We found 588 articles, 44 were included. Most reports were 2013, 96% in Asia, median age of 6.3 years (0.3-13.6). 2899 of dengue cases were reported, 250 cases had liver failure. Dengue severity on arrival 2,8% were without warning signs, 16% had warning signs and 79% were severe dengue. INR mean value peaked to 3.7 at day 7 and 71% has encephalopathy described. 5.6% died of all patients with dengue. The median aminotransferases peak level found was 2653 u/L (208-10500 U/L) on day 5 (1-17) of illness with a median hospital length of stay of 11 days (1-27 days). Management was supportive, in two cases N-acetylcysteine was used. None of the patients had a liver transplant, but most regions report that they had no liver transplantation programs at that time. Conclusions: Liver failure from dengue is a rare complication worldwide, but relevant in endemic populations such as Colombia. It is important to understand these complications to offer timely support.