The oral cancer is the 6th most incident cancer type in the world and is most prevalent among men than in women. Usually screening procedures are performed only in advanced stages which leads to an increase of mortality and morbidity. Analyzing images from 20 patients we conclude that the observed optical image (conventional microscope or smartphone) of the formed pattern enables discrimination of oral cancer in few hours. It represents a non-invasive diagnostic method which minimizes hospital medical procedures, hospitalizations and patient discomfort.