Aims & Objectives: ECMO is a support modality used within the pediatric cardiac ICU as a bridge for recovery. Indications include lack of separation of cardiopulmonary bypass, low refractory cardiac output syndrome, hemodynamically unstable arrhythmias or cardiopulmonary cardiopulmonary resuscitation (eCPR). Patients with bidirectional Fontan and Glenn present additional challenges for both the extracorporeal membrane and the Cannulation and oxygenation support. The objective of the study is to inform the experience of a cardiovascular center in patients with cavopulmonary connections who received ECMO. Methods: Case series study takes the clinical records of patients admitted to the pediatric cardiac ICU; in the period 2018 to 2020, with cavopulmonary connections (Fontan or Glenn bidirectional) and need for support with ECMO. Results: A total of 6 patients. Age between 4 and 93 months, 5 male sex and 1 female sex. In 5 patients (83.3%) the decannulation successfully, and 1 patient (16.6%) who dies with bidirectional Glenn due to refractory shock The ECMO VA time was 150 hours (112-370 hours) and the indications are: 4 Patients (66.6%) had low postoperative syndrome, 1 patient (16.6%) unable to withdraw from the extracorporeal circulation Conclusions: Patients with bidirectional Glenn and Fontan physiology present significant challenges for success in supporting ECMO. While morbidity and mortality rates are high, there are selected patients for whom extracorporeal support can be effective and save lives as a short-term resuscitation intervention