The current carbon capture and utilization (CCU) approaches are based on the versatility of CO2 as a chemical feedstock, which can be transformed into different useful chemicals such as methanol, methane, formic acid, or CO. These cited approaches can be continuously enhanced by means of the optimization of process variables, in order to promote the global performance in terms of yield and selectivity. Pressurization is one of those variables that can be optimized for the improvement of the CO2 transformation reactions, in order to enhance the solubility and favor the phase conditions of the components involved, changing selectivity and reaction rate. This chapter presents the thermodynamic aspects of the use of pressurization in CO2 hydrogenation reactions. In addition, an overview of the current use of this technology in the industry and finally a techno-economic analysis are discussed for the high-pressure CO2 hydrogenation toward methanol following a CCU strategy.