ABSTRACT Catheter-directed thrombectomy is a novel promising therapy with little published experience. Previous reports have described it as a useful tool in high risk patients in need of intravascular material resection. Here we present a unique and never reported case of AngioVac device thrombectomy use in a patient with right atrial catheter-associated thrombus and gastrointestinal bleed that contraindicated other thrombectomy therapies due to severe anemia and high bleeding risk. A brief literature review about this therapy and its main outcomes is presented to contextualize the reader and contribute to academic knowledge.