Background: Dyslipidemia is a metabolic disorder with significant prevalence worldwide. Statins have been described to be the primary lipid lowering drugs. Therefore, it is important to know their use and the presence of drug-related problems (DRPs) associated with their use. The objective of this study was to determine association of DRPs with the use of statins and with other risk factors [such as dietary habits and cardiovascular disease (CVD) risk score]. Methods: A retrospective and descriptive study was carried out in a primary healthcare centre, with the utilization of patient records containing information on high blood pressure (HBP), diabetes mellitus (DM) or dyslipidemia, and CVD risk (Framingham risk score, FRS), in which DRPs of statins and other prescribed drugs concomitantly were detected. A descriptive bivariate analysis was performed to associate the occurrence of DRPs with demographics and clinical factors and their compliance with diet/exercise and other risk factors. Results: A total of 79 DRPs associated with the use of statins were identified in 132 patients and at least one DRP was detected in 60 patients (45%). Most of them belonged to the effectiveness category (42%) followed by the indication category (27%). When logistic regression was applied, only age and Framingham CVD risk score were associated with DRPs (P=0.05 and 0.04 respectively). Conclusions: A high proportion of patients with DRPs were identified, mainly due to inadequate dosage of statins, therapeutic non-compliance and need for a statin prescription. Adherence to diet/exercise was not related with DRPs, however age and high CVD Framingham score was associated with DRPs.