This chapter presents the fundamental elements related to the success factors of social organizations. The first step was bibliographic research on social entrepreneurship. This research established that social entrepreneurship improves the quality of life of vulnerable communities, which stands out for the social construction of products, services, and processes that allow social inclusion. Social entrepreneurship in Colombian companies has become a topic of analysis; however, it is still a developing area. The second step was to conduct a quantitative and descriptive investigation in the Colombian coffee region, specifically in the departments of Caldas, Risaralda, and Quindío. The sample distribution of the proportions determined the sample. The information was collected from non-profit companies. The results showed that the success factors are to offer quality services, to have committed human talent, and the adequate management of resources that the competitive advantage is the social need they satisfy, and the social benefit is the reduction of poverty.