The Jesuit province of Paraquaria included missions established within both sedentary and non-sedentary indigenous groups. This study examines the Guenoa Minuanos and their interactions with the Jesuit mission San Francisco de Borja. The Guenoa Minuanos were a non-sedentary group that lived in the Banda Oriental, or what is today Uruguay and Rio Grande do Sul. Some bands chose to settle on the missions and particularly San Francisco de Borja, while other bands allied with the Portuguese. This study focuses on the bands that settled on the San Francisco de Borja mission.