Due to the crisis of traditional mediations of religious experience, we are witnessing a more and more generalized spiritual search, derived from the tendency to ultra-individualism, with the aim of self-realization. In response to such a situation, this writing collects the results of an investigation that, with the background of the intuition of the mystical future of humanity, approaches the experience of six spiritual witnesses of yesterday and today: Gregory of Nyssa, Ignatius of Loyola, Teresa of Jesus, Etty Hillesum, Laura Montoya, and Benjamín González Buelta. The approach investigated the characteristics of the mystical experience, understood as awareness of presence, to identify keys capable of contributing to the renewal of spiritual experience today.