Through Deleuze’s and Guattari’s concept of body without organs, this paper proposes that René’s Flesh, a novel written by Virgilio Piñera, establishes a necropolitical violence framework that leads the bodies affiliated to The Cause to articulate resistance to this violence. This interpretation also relies on Achille’s Mbembe concept of necropolitics, as well as Deleuze’s and Guattari’s concepts of body and territory, to point out that the assimilation of violence to life as a means of resistance prevents the body from being conceived as a place of life.