In this work, we provide a formal approach to the econometric relationship between the volume of rainfall and occupational diseases in Colombia for the period 2010 – 2014. Our main result is that, with a random effects panel data model at the municipal level with month – by – month and year – by – year effects, we obtained evidence of an increase in occupational diseases due to an increasing volume of rainfall. Finally, we bring outlines for future research in this topic.