Interpolation tools are used daily in hydrology and climatology.With the purpose to regionalize spot´s registration parameters, such as depth of precipitation, temperature, humidity, among others.The accuracy of these methods is not fully validated.This research presents a comparative study between the most used interpolation methods for the regionalization of hydrological and climatological parameters.Comparative analysis of spatial interpolation; it was carried out using the IDW, Kriging and Spline methods, for this the ARGIS software was used, because its widespread and widespread use.The depth of precipitation was considered as a parameter for the comparison.Accuracy was determined by cross validation.Also, for the coefficient of determination and the comparison for visual errors such as "bull's eyes".The research was spatially restricted to a politically delimited region; Boyacá, Colombia, South America.The best method for spatial interpolation in this case was shown to be Spline.