The solubility of triclocarban (TCC) was determined in {ethylene glycol (EG) + water} cosolvent mixtures at 7 temperatures (288.15–318.15 K). The solubility of TCC increases with increasing temperature and the polarity of the cosolvent system decreases with increasing EG concentration. In that case, TCC reaches its minimum solubility in pure water at 288.15 K and maximum solubility in EG at 318 K. The thermodynamic functions were calculated using the van Hoff equation, and it was determined that the process is endothermic and, according to entropy enthalpy compensation analysis, is driven by entropy in water-rich mixtures, and by enthalpy in intermediate and EG-rich mixtures. According to transfer functions, TCC tends to transfer from polar to less polar media. Regarding preferential solvation analysis, carried out using the IKBI model, TCC is preferentially solvated by water in water-rich mixtures and by EG in intermediate and EG-rich mixtures.