In recent years, several closed loop control strategies have been developed in order to maintain a health glucose level in type 1 diabetic mellitus (T1DM) patients. However, a feedback controller itself is unable to define a postprandial (after a food intake) glucose trajectory. Thus, in this paper a new control approach is defined by using two main blocks: a MPC feedback/feed-forward controller and a carbohydrate intake estimator. Then, by estimating moment and amount of intake of carbohydrates, on one hand, such disturbance is compensated and on other one, a healthy subject profile is generated for being followed by the MPC feedback controller. One of the advantages of using a glucose profile in place of a fixed glucose reference is that quantity of infused insulin could be lower and distributed along the time, which could avoid hypoglycemia episodes. Finally, an in-silico validation of the control approach was achieved by using glucose dynamics models provided by the T1DMS UVA/Padova simulator (Accepted by Food & Drug Administration).