This document presents the results of a research process on the state of the art of innovation systems, technology transfer, and intermediation, which take place in the development of activities aimed at seeking innovation options in the different productive sectors, through articulation between the different actors of the university, the industry, and the state. In this sense, and making use of Scopus, Web of Science, and Google Scholar databases, a set of documents was obtained through which it was possible to identify: concepts on innovation systems, aspects that intervene in the transfer processes of technology that is especially related to the articulation of actors of the quadruple helix, as well as how these issues are adopted from the Colombian norms in the agro-industrial sector.