We list 102 currently known Opostegidae species from the Americas, designate one new species group, and revise and provide pictorial diagnostics for the twelve Pseudopostega Kozlov species groups. Five new species are described: Neopostega dondavisi Stonis and Remeikis, new species, Pseudopostega cucullata Stonis and Vargas, new species, Pseudopostega bogotensis Vargas, new species, Pseudopostega bifida Stonis and Remeikis, new species, and Pseudopostega spinosa Stonis and Diškus, new species. We provide new distributional data and the first photographic documentation of Pseudopostega ovatula Davis and Stonis, P. monstruosa Davis and Stonis, P. sacculata (Meyrick), P. fumida Davis and Stonis, P. paraplicatella Davis and Stonis, P. apotoma Davis and Stonis, P. diskusi Davis and Stonis, P. sublobata Davis and Stonis, P. didyma Davis and Stonis, P. denticulata Davis and Stonis, P. ecuadoriana Davis and Stonis, and P. venticola (Walsingham). We briefly discuss available molecular data, history of species descriptions, and provide species numbers for countries in the Western Hemisphere.