This work aims to present the results of the application of the RISE model (innovation and business sustainability route) in 25 global purpose-driven micro, small, and medium-sized Bogotanas companies, beneficiaries of the Innova District project and its impact on the net margin. The working hypothesis is the management of innovation and sustainability has some impact on the net margin of the global purpose-driven micro, small, and medium-sized Bogotanas enterprises. It is a preliminary analysis, the findings and conclusions that were made based on the description of results and development of polynomial regressions only generated conclusive elements for the population of companies analyzed and the characteristics of the research proposed. However, the proposed hypothesis was verified for a group of companies, while, for a second group, the correlation between innovation and sustainability and the net margin was relatively low or almost nil.