The persistence of innovation is a topic that has been used in recent years. Companies must be in continuous production of innovations to achieve a competitive advantage in the market and for this, it is necessary to have elements that positively influence the persistence of innovating. The objective of the article is to describe the elements that positively influence the persistence of innovation through a systematic literature review in the range of the last 10 years (2010–2019). As a result, 34 articles were obtained and it was identified that investment in R & D, human resources and knowledge management positively influences the persistence of innovation.