Sir, Due to rapid increase in the number of people infected with COVID-19 worldwide, anxiety and concern are increasing among the population in various regions of the world. They have made this pandemic an unprecedented global public health problem. The extremely high infection rate, the mortality associated with COVID-19, and the pandemic nature of the situation exacerbate fear in all sectors of the population, which has led to stigma-discrimination complex (SDC) in some social sectors, in particular, and conspicuously, toward workers in the health sector.[1] The SDC is an idea related to four terms that bring together, are highly correlated, and often happen simultaneously: stigma, stereotype, prejudice, and discrimination. Stigma is an unfavorable attribute, prejudice is a pejorative personal judgment based on stigma, a stereotype is a negative social attitude toward the negative feature, and discrimination implies behaviors violating rights of persons or groups with the stigmatized characteristic.[2] As the COVID-19 outbreak increases, a wave of fear emerges that leads to the development of new forms of stigma-discrimination in various communities.[1] Although nobody wants to be infected with a virus with high morbidity and mortality rates, people's behavioral responses are disproportionate.[3] Thus, the SDC associated with COVID-19 has taken over the social conscience and is overgrowing worldwide, notwithstanding the scientific evidence showing the nature of COVID-19. The SDC associated with COVID-19 presents undesirable social consequences that jeopardize efforts to halt the advance of the pandemic.[4] The SDC has an emotional and cognitive impact that affects the ability to assess situations associated with COVID-19 objectively, and this limits the potential for the effectiveness of the prevention and mitigation strategies that each citizen must follow.[1] In addition, it is essential to highlight that the SDC toward symptomatic people of COVID-19 limits the search for medical help.[5] So far, the COVID-19 approach has focused primarily on infection control and effective vaccine design.[5] Meanwhile, the psychosocial aspects have not been studied in-depth or sufficiently;[1] thus, states will have to work holistically to reduce the transmission rate of COVID-19 and guarantee the highest degree possible of social welfare. All social groups must commit to the design of effective fear reduction and SDC programs associated with COVID-19 to modify the social perception of the epidemic. Clear, scientifically substantiated and transparent information should be provided to the general population, while favorable, encouraging messages of support should disseminate to all members of society, especially health personnel and other essential workers.[14] Given the scarcity of interventions to reduce the associated SDC toward COVID-19, there is a need for structured related programs and to take advantage of the current position of social networks to overcome fear and stigma.[4] Under this perspective, academics, policymakers, researchers, and health professionals should lead these programs to combat misinformation, SDC, and fear related to COVID-19. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.