Two morphologically similar halophilic strains, named USBA 874 and USBA 960 T , were isolated from water and sediment samples collected from the Zipaquirá salt mine in the Colombian Andes. Both isolates had non-spore-forming, Gram-stain-negative and motile cells that grew aerobically. The strains grew optimally at 30 °C, pH 7.0 and with 25 % NaCl (w/v). The isolates showed almost identical 16S rRNA gene sequences (99.0 % similarity). The predominant quinones of USBA-960 T were Q-8, Q-7 and Q-9. The major cellular fatty acids were C 19 : 0 cyclo ω 8 c , C 18 : 0 and C 16 : 0 . According to 16S rRNA gene sequencing, the closest phylogenetic relatives are Salinisphaera species (similarity between 93.6 and 92.3 %), Abyssibacter profundi OUC007 T (88.6 %) and Oceanococcus atlanticus 22II-S10r2 T (88.7 %). In addition, the result of genome blast distance phylogeny analysis between strains USBA 874 and USBA 960 T , Salinisphaera halophila (YIM 95161 T ), Salinisphaera shabanensis (E1L3A T ), Salinisphaera orenii (MK-B5 T ) and Salinisphaera japonica (YTM-1 T ) was 18.5 %. Other in silico species delineation analyses also showed low identity such as ANIb and ANIm values (<69.0 and <84.0 % respectively), TETRA (<0.81) and AAI values (<0.67). Genome sequencing of USBA 960 T revealed a genome size of 2.47 Mbp and a G+C content of 59.71 mol%. Phylogenetic analysis of strains USBA 874 and USBA 960 T indicated that they formed a different lineage within the family Salinisphaeraceae . Based on phenotypic and chemotaxonomic characteristics, phylogenetic analysis and DNA–DNA relatedness values, along with identity at whole genome level, it can be concluded that strains USBA 960 T and USBA 874 represent a novel genus of the family Salinisphaeraceae and the name Salifodinibacter halophilus gen. nov., sp. nov. is proposed. The type strain is USBA 960 T (CMPUJ U095 T =CECT 30006 T ).