In developing countries, horticultural production in low-altitude tropical climate conditions is often limited by biotic and abiotic factors. In these countries, the implementation of highly technical greenhouses is not feasible due to economic, social and cultural issues related to farmers. Therefore, one of the alternatives that has taken a great boom is the use of screen house structures (SH), although information on the microclimatic behavior of these is still limited. The objective of this research was to use an experimentally validated 3D CFD numerical simulation model to study the thermal behavior and airflow patterns in an SH located in the Colombian Caribbean region during the daytime hours (6:00 to18:00 h). The results obtained showed that the air flow patterns inside the SH showed speed reductions of up to 68% with respect to the speed of the external wind. It was also found that the thermal behavior inside the SH was quite homogeneous, the average temperature values in the structures ranged between 23.9 and 39 °C and the difference with external environment temperature did not exceed 1.8 °C. It was concluded that the implementation of this type of structure could be an useful technological tool for the optimization of horticultural production in low-altitude tropical climate regions.